Dawn Lowe, PhD

Director of Graduate Studies, Associate Professor, Division of Physical Therapy

Dawn Lowe

Contact Info

lowex017@umn.edu

Office Phone 612-626-3344

Fax 612-624-0632

Office Address:
Division of Physical Therapy
311 Children's Rehab Ctr
426 Church Street SE
Minneapolis, MN 55455

Mailing Address:
Division of Physical Therapy
MMC 388
420 Delaware St SE
Minneapolis, MN 55455

Director of Graduate Studies, Associate Professor, Division of Physical Therapy

Rehabilitation Science


Postdoctoral Fellow, University of Minnesota (Biochemistry), 1998; Postdoctoral Fellow, University of South Florida (Muscle Biology), 1995

PhD, University of Georgia (Exercise Science), 1994

MS, University of Texas (Clinical Exercise Physiology), 1990

BS, Ferris State University (Applied Biology), 1988

Summary

Professional Associations

Fellow of the American College of Sports Medicine
Member of the American Physiological Society
Member of the Paul and Sheila Wellstone MDCenter, University of Minnesota
Member of Scientists in Aging Research, University of Minnesota
Member of Powell Center for Women's Health, University of Minnesota
Graduate Faculty Member, Rehabilitation Science, University of Minnesota
Graduate Faculty Member, Kinesiology, University of Minnesota
Graduate Faculty Member, Gerontology, University of Minnesota
Graduate Faculty Member, Integrative Biology and Physiology
Editor, Experimental Physiology (journals.physoc.org)
Director of Graduate Studies for Rehabilitation Science

Research

Research Summary/Interests

Broadly defined, my research interests include muscle physiology, aging, muscular dystrophy, and exercise science. The focus of this research is cellular and molecular mechanisms underlying skeletal muscle deterioration that occur with age, injury, and disease. Current studies are also aimed at preventing or reversing this muscle deterioration through exercise and pharmacological interventions.

Research Funding Grants

Current Funded Research:

NIH, R01 2AG031743-06. "Interaction of Estrogen, Age and Activity on Musculoskeletal Strength in Females”. 02/01/2009 to 01/31/2019

Bob Allison Ataxia Research Center, Faculty Grant, “Inexcitability of the Muscle Plasmalemma and Strength Loss in Duchenne Muscular Dystrophy”

Publications

Publications Within the Last 3 Years:

  • Lai, S., B.C. Collins, B.A. Colson, G. Kararigas, and D.A. Lowe. Estradiol modulates myosin regulatory light chain phosphorylation and contractility in skeletal muscle of female mice. Am. J. Physiol. Endocrin. Metabolism. In Press, March 2016. PMID 26956186.
  • Dandapat, A., B.J. Perrin, C. Cabelka, M. Razzoli, J.M. Ervasti, A. Bartolomucci, D.A. Lowe, and M. Kyba. High frequency hearing loss and hyperactivity in DUX4 transgenic mice. PLOS ONE 11(3): e0151467, 2016.PMID 26978271.
  • Valencia, A.P., A. E. Schappal, E.M. Morris, J.P. Thyfault, D.A. Lowe, and E.E. Spangenburg. The presence of the ovary prevents hepatic mitochondrial oxidative stress in young and aged female mice through glutathione peroxidase 1.Exp. Gerontol. 73: 14-22, 2016. PMID 26608809.
  • Houang, E.M., K. Haman, A. Filareto, R.C. Perlingeiro, F.S. Bates, D.A. Lowe, and J.M. Metzger. Membrane-stabilizing copolymers confer marked protection to dystrophic skeletal muscle in vivo. Mol. Ther. Methods Clin. Dev. 2:15042, 2015. PMID 26623440. PMC4641511.
  • Colson, B.A., K.J. Petersen, B.C. Collins, D.A. Lowe, and D.D. Thomas. The myosin super-relaxed state is disrupted by estradiol deficiency. Biochem. Biophys. Res. Comm. 456: 151-155, 2015. PMID 25446114. PMC4276479.
  • Kosir, A.M, T.L. Mader, A.G. Greising, S.A. Novotny, K.A. Baltgalvis, and D.A. Lowe. Influence of ovarian hormones on strength loss in healthy and dystrophic female mice. Med. Sci. Sport Exerc. September, 2014 Epub ahead of print. PMID 25255128. PMC4372520.
  • Mader, T.L, S.A. Novotny, A.S. Lin, R.E. Guldberg, D.A. Lowe, and G.L. Warren. CCR2 elimination in mice results in larger and stronger tibial bones but bone loss is not attenuated following ovariectomy or muscle denervation. Calcif. Tissue Int. 95: 457-466, 2014. PMID 25234653. PMC4228687.
  • Dandapat, D.A, D. Bosnakovski, K.A. Baltgalvis, D. Vang, L. Harweck, N. Nash, R. Darabi, R.C. Perlingeiro, F.K. Hamra, K. Gupta, D.A. Lowe, and M. Kyba. Dominant lethal pathologies in male mice engineered to contain an X-linked DUX4 transgene. Cell Rep. 8: 1484-1496, 2014. PMID 25176645. PMC4188423.
  • Belanto, J.J, T.L. Mader, M.D. Eckhoff, D.M. Strandjord, G.B. Banks, M.K. Gardner, D.A. Lowe, and J.M. Ervasti. Microtubule binding distinguishes dystrophin from utrophin. PNAS 111: 5723-5728, 2014. PMID 24706788. PMC3992671.
  • Novotny, S.A., T.L. Mader, A.G. Greising, A.S. Lin, R.E. Guldberg, G.L. Warren, and D.A. Lowe. Low intensity, high frequency vibration training to improve musculoskeletal function in a mouse model of Duchenne muscular dystrophy. PLoS One 9(8): e104339, 2014. PMID 25121503. PMC4133244.
  • Gordon, B.S., D.A. Lowe, and M.C. Kostek. Exercise increases utrophin protein expression in themdx mouse model of Duchenne muscular dystrophy. Muscle Nerve 49:915-918, 2014. PMID 24375286. PMC in process.
  • Novotny, S.A., H. Mehta, D.A. Lowe, and D.J. Nuckley. Vibration platform for mice to deliver precise, low intensity mechanical signals to the musculoskeleton. J. Musculoskel. Neuronal Interact. 13:412-417, 2013. PMID 24292611. PMC in progress.
  • Novotny, S.A., M.D. Eckhoff, B.C. Eby, J.A. Call, D.J. Nuckley, and D.A. Lowe. Musculoskeletal response of dystrophic mice to short term, low intensity, high frequency vibration. J. Musculoskel. Neuronal Interact. 13:418-429, 2013. PMID 24292612. PMC in progress.
  • Tiidus, P. D. A. Lowe, M. Brown. Estrogen replacement and skeletal muscle: Mechanisms and population health (Synthesis Review). J. Appl. Physiol. 115:569-578, 2013. PMID 23869062. PMC in process.
  • Call, J.A., G.L. Warren, M. Verma, and D.A. Lowe. Acute failure of action potential conduction inmdx muscle reveals new mechanism of contraction-induced force loss. J. Physiol. 591:3765-3776, 2013. PMID 23753524.
  • Arpke, R.W., R. Darabi, T. Mader, K.T. Haider, A. Toyama, C. Lonetree, N. Nash, D.A. Lowe, R.C. Perlingeiro, and M. Kyba. A new immuno- dystrophin-deficient model, the NSG-mdx4Cv mouse, provides evidence for functional improvement following allogeneic satellite cell transplantation. Stem Cells. doi: 10.1002/stem.1402. 2013. PMID 23606600.
  • McKeehen, J.N., S.A. Novotny, K.A. Baltgalvis, J.A. Call, D.J. Nuckley and D.A. Lowe. Adaptations of mouse skeletal muscle to low intensity vibration training. Med. Sci. Sport Exerc. 45: 1051-1059, 2013. PMID 23274599.

Teaching

Courses

Scientific Foundations I: Theory of Exercise