Wynn Legon, PhD

Assistant Professor, Division of Physical Therapy

Wynn Legon

Contact Info


Office Phone 612-626-1183

Fax 612-625-4274

Office Address:
Program in Physical Therapy
University of Minnesota
398 Children's Rehab Center
MMC 388
420 Delaware St. SE
Minneapolis, MN 55455

Assistant Professor, Division of Physical Therapy

MnDRIVE Brain Conditions Neuromodulation Scholar

Postdoctoral Fellowship, Sunnybrook Health Sciences Centre - Center for Stroke Recovery, Ontario, Canada; Postdoctoral Fellowship, Virginia Tech Carilion Research Institute

PhD, University of Waterloo, Ontario, Canada (Kinesiology, Cognitive and Behavioural Neuroscience)

MS, York University, Ontario, Canada (Kinesiology and Health Science)

BA, York University, Ontario, Canada (Kinesiology and Health Science)


Awards & Recognition

  • Natural Sciences and Engineering Research Council of Canada (NSERC) - Post-Graduate Scholarship 7/2009
  • University of Waterloo - Post Graduate Scholarship 7/2009

Professional Associations

  • Society for Neuroscience
  • Organization for Human Brain Mapping
  • The Federation of European Neuroscience Societies


Research Summary/Interests

I am primarily interested in developing and advancing transcranial focused ultrasound for non-surgical neuromodulation in humans. My current research investigates combining tFUS with MRI as well as developing tFUS for stimulation of sub-cortical structures. The ultimate goal of this research is to translate these findings to clinical populations for therapeutic use. In addition, I also conduct research using conventional non-invasive neuromodulatory technologies like TMS and tD/ACS. This research looks at the effect of individual gyral anatomy on electric fields to advance subject-specific neuromodulation. Finally, I have a particular interest in the frontal cortex and how modulation of frontal areas through either disease, age or neuromodulation affect both local and downstream neuronal circuits and ultimately behavior. This research uses a multidisciplinary approach including neuromodulatory techniques TMS, tDCS and tFUS in combination with EEG, evoked potential, fMRI as well as computational methods including finite element modelling (FEM) and dynamic causal modelling (DCM).


Selected Publications:

  • Mueller J. Legon W. Opitz A. Sato T.F. Tyler W.J. (2014).Transcranial focused ultrasound modulates intrinsic and evoked EEG dynamics. Brain Stimul. (In press).
  • Legon W. Sato T.F. Opitz A. Mueller J. Barbour A. Williams A.Tyler W.J.(2014). Transcranial focused ultrasound modulates the activity of primary somatosensory cortex in humans. Nature Neuroscience. 17, 322-329. doi:10.1038/nn.3620
  • Legon W. Dionne J.K. and Staines W.R. (2013). Continuous theta burst stimulation of the supplementary motor area: effect upon perception and somatosensory & motor evoked potentials. Brain Stimul, Nov; 6 (6): 877-83. doi: 10.1016/j.brs.2013.04.007
  • Opitz A. Legon W. Rowlands A. Paulus W. Bickel W. and Tyler W.J. (2013). Physiological observations validate finite element models for estimating subject-specific electric field distributions induced by transcranial magnetic stimulation of the human motor cortex. NeuroImage, Nov 1; 81: 253-64. doi: 10.1016/j.neuroimage.2013.04.067
  • Legon W. Rowlands A. OpitzSato T. Tyler W.J. (2012). Pulsed ultrasound differentially stimulates somatosensory circuits in humans as indicated by EEG and fMRI. PLoS One.2012;7(12): e51177.DOI: 10.1371/journal.pone.0051177
  • Dionne J.K. Meehan S.K. Legon W. Staines W.R. (2009).Crossmodal influences in somatosensory cortex: interaction of vision and touch. Hum Br Mapp31 (1) 14-25.


Teaching Areas

Instrumentation and Methodology in Rehabilitation Science