Gillick Pediatric Research Lab
In the Gillick Pediatric Research Lab, we believe that all children with cerebral palsy have the potential to influence their level of function throughout their lifetime.
Bernadette Gillick and her fellow researchers are focused on making a significant, positive impact on the lives of children with cerebral palsy through advancing neurorehabilitation. Inquiries and discussions are welcome, without obligation of participation.
Dr. Gillick, McKnight Land-Grant Professor, has been named a Representative on the Global Professional Education Committee for the International Alliance of Academies of Childhood Disability. This Alliance represents the American/Canadian, Australasian and European Academies of Cerebral Palsy, Developmental Medicine and Childhood Disability. Her role will involve promoting a global standard of multi-disciplinary education and dissemination surrounding interventions for children with disabilities and their families. In addition, Dr. Gillick has been awarded the Eugene Michels Outstanding New Investigator Award from the American Physical Therapy Association (APTA). This national award recognizes outstanding contributions to research related to the physical therapy profession.
- Gillick Lab Cerebral Palsy study is featured in Star Tribune's news article. Read more about it here.
- Our main NIH K01 research project, tDCS/CIMT in Cerebral Palsy, has now been completed, published and highlighted by the NIH (links below). This was a study in the making since 2011, with the K01 commencing in 2015. Over 50 investigators and collaborators contributed to this research, with the dedication of 20 enrolled children and their families from across the United states. As PI, I am very grateful for the efforts dedicated to this cause and wanted to extend my most heart-felt appreciation. May we continue to develop robust and durable interventions for these children across the lifespan, integrating words such as 'cure' and 'prevent' like never before. Read more about the study on the Eunice Kennedy Shriver National Institute of Child Health and Human Development page and European Journal of Paediatric Neurology.
- Gillick Lab Infant Study featured on KARE 11 News. Click HERE to see the video.
- Gillick B, Rich T, Nemanich S, Chen CY, Menk J, Mueller B, Chen M, Ward M, Meekins G, Feyma T, Krach L, Rudser K. Transcranial direct current stimulation and constraint-induced therapy in cerebral palsy: A randomized, blinded, sham-controlled clinical trial. Eur J Paediatr Neurol. 2018 May;22(3):358-368. doi: 10.1016/j.ejpn.2018.02.001. Epub 2018 Feb 11. PubMed PMID: 29456128; PubMed Central PMCID: PMC5899638.
- Rich TL, Menk JS, Rudser KD, Feyma T, Gillick BT. Less-affected hand function in children with hemiparetic cerebral palsy: A comparison study to typically developing peers. Neurorehabil Neural Repair. 2017 Oct-Nov;31(10-11):965-976.
- Rich T, Menk J, Rudser KD, Chen M, Meekins GD, Pena E, Feyma T, Bawroski K, Bush C, Gillick BT. “Determining electrode placement for transcranial direct current stimulation: A comparison of electroencephalogram versus transcranial magnetic stimulation-guided methods”. Clinical EEG and Neuroscience. 2017 Nov;48(6):367-375.
- Bikson M, Grossman P, Zannou AL, Kronberg G, Truong D, Boggio P, Brunoni AR, Charvet L, Fregni F, Fritsch B, Gillick B, Hamilton RH, Hampstead BM, Kirton A, Knotkova H, Liebetanz D, Liu A, Loo C, Nitsche MA, Reis J, Richardson JD, Rotenberg A, Turkeltaub PE, Woods AJ. Response to letter to the editor: Safety of transcranial direct current stimulation: Evidence based update 2016. Brain Stimul. 2017 Sep - Oct;10(5):986-987. doi: 10.1016/j.brs.2017.06.007. Epub 2017 Jul 12. PubMed PMID: 28734680.
- Chen CY, McGee C, Rich T, Prudente C, Gillick BT. “Reference Values of Intrinsic Muscle Strength of the Hand of Adolescents and Young Adults”. Journal of Hand Therapy, 2017 Aug 12. pii: S0894-1130(17)30016-9.
- Chen CY, Georgieff M, Elison J, Chen, M, Stinear J, Mueller, B, Rao, R, Rudser K, Gillick B. Understanding Brain Reorganization in Infants with Perinatal Stroke through Neuroexcitability and Neuroimaging: Study Protocol. Pediatric Physical Therapy. 2017 April; 29(2): 173-178
- Froehle E, Gillick B. "Research" what you say: I did not suffer a stroke., I survived one. Journal of Humanities in Rehabilitation. November 30, 2016
- Chen CY, Rich TR, Cassidy JM, Gillick BT. Corticospinal Exitability in Children with Congenital Hemiparesis. Brain Sci. 2016 Oct; 20; 6(4)
- Bikson M, Grossman P, Thomas C, Zannou AL, Jiang J, Adnan T, Mourdoukoutas AP, Kronberg G, Truong D, Boggio P, Brunoni AR, Charvet L, Fregni F, Fritsch B, Gillick B, Hamilton RH, Hampstead BM, Jankord R, Kirton A, Knotova H, Liebetanz D, Liu A, Loo C, Nitsche MA, Reis J, Richardson JD, Rotenberg A, Turkeltaub PE, Woods, AJ. Safety of Transcranial Direct Currrent Stimulation: Evidence Based Update 2016. Brain Stimulation, 2016 Sep-Oct; 9(5):641-61
- Rich T, Cassidy J, Menk J, Heest AV, Krach L, Carey J, Gillick BT. Stability of stereognosis after pediatric repetitive transcranial magnetic stimulation and constraint-induced movement thearpy clinical trial. Developmental Neurorehabilitation. 2016 Mar. 17:1-4.
- Rich TL, Menk J, Krach LE, Feyma T, Gillick BT. Repetitive Transcranial Magnetic Stimulation/Behavioral Invervention Clinical Trial: Long-Term Follow-Up of Outcomes in Congenitial Hemiparesis. Journal of Child and Adolescent Psychopharmacology. 2016 Sep. 26(7); 598-605
- Gillick BT, Rich T, Chen M, Meekins GD. Case report of vasovagal syncope associated with single pulse transcranial magnetic stimulation in a healthy adult participant. BMC Neurol. 2015 Dec 1;15:248. doi: 10.1186/s12883-015-0510-2. PubMed PMID: 26627895; PubMed Central PMCID: PMC4666029.
- Gillick B, Menk J, Mueller B, Meekins G, Krach LE, Feyma T, Rudser K. Synergistic Effect of Combined transcranial Direct Current Stimulation/Constraint-Induced Movement Therapy in Children and Young Adults with Hemiparesis: Study Protocol. BMC Pediatrics. 2015. 15(178); 1-10
- Cassidy JM, Carey JR, Lu C, Krach LE, Feyma T, Gillick BT. Ipsilesional Motor-Evoked Potential Absence in Pediatric Hemiparesis Impacts Tracking Accuracy of the Less Affected Hand, Research in Developmental Disabilities, 2015;47: 154-164.
Summary: In this study, we evaluated the children from our repetitive Transcranial Magnetic Stimulation (rTMS)/Constraint-Induced Movement Therapy (CIMT) clinical trial using MRI, a finger tracking task, and TMS testing. TMS testing allows us a “window into the brain” to learn if the child has preserved corticospinal tract input to the more-affected hand. We learned that the group of children who had preserved corticospinal tract input (identified with a motor evoked potential on their lesioned hemisphere), had greater volumes in brain structures as compared to the group of children who did not have preserved corticospinal tracts. The difference in volumes was associated with reduced ability to accurately complete a finger tracking task with their less-affected hand.
- Gillick BT, Feyma T, Menk J, Usset M, Vaith A, Wood, T. Worthington R, Krach LE. Safety and Feasibility of Transcranial Direct Current Stimulation in Pediatric Hemiparesis: A Randomized, Controlled Pilot Study. Physical Therapy. 2015; 95(3):337-349
Summary: Pilot study incorporating our computerized modeling outcomes to investigate safety and feasibility using a form of non-invasive brain stimulation called transcranial direct current stimulation (TDCS). TDCS has not previously been investigated in children with hemiparesis. No serious adverse events occurred, and no decline in cognitive or motor function was found. Minor adverse events are described.
- Gillick BT, Kirton A, Carmel J, Minhas P, Bikson M. Pediatric Stroke and transcranial Direct Current Stimulation: Methods for Rational Individualized Dose Optimization. Frontiers of Neuroscience. 2014 sep. 19; 8:739.
Summary: Study which created a computerized model of a brain in order to establish optimal safety for the dose of non-invasive brain stimulation called transcranial direct current stimulation
- Gillick, BT, Krach LE, Feyma T, Rich TR, Moberg KJ, Menk J, Cassidy J, Kimberley T, Carey JR. Safety of primed repetitive transcranial magnetic stimulation and modified constraint-induced movement therapy in a randomized controlled trial in pediatric hemparesis. Archives of Physical Medicine and Rehabilitation. 2015 Apr; 96(4 Suppl):S104-13
Summary: Expansion of description from our original publication, specific to safety. No serious adverse events occured in our rTMS/CIMT study which used a form of non-invasive brain stimulation called repetitive transcranial magnetic stimulation combined with constraint--induced therapy. The procedures we used to work with establishing and analyzing safety in our study and minor adverse events which are further described.
In response: A commentary article - Hoare, B. Putting some excitement into constraint-induced movement therapy. Developmental Medicine and Child Neurology. 2014; 56(1)5-6 doi:10.1111/dmcn.12272
Summary: Comments from an international expert on the novelty and outcomes related to our work.
- Gillick BT, Krach LE, Feyma T, Rich TL, Moberg K, Thomas W, Cassidy JM, Menk J, Carey JR. Primed Low-Frequency Repetitive Transcranial Magnetic Stimulation and Constraint-Induced Movement Therapy Randomized Trial for Pediatric Hemiparesis. Developmental Medicine and Child Neurology. 2014; 56(1):44-52 PMID: 23962321
Summary: Description of the changes in hand function and other measures in our rTMS/CIMT study. This study used a form of non-invasive brain stimulation called repetitive transcranial magnetic stimulation (rTMS) combined with constraint-induced movement therapy (CIMT). We found that this intervention was well-tolerated and that 8 of 10 children in the intervention group showed significant improvements in hand function. No serious adverse events occurred, with the most common minor adverse events being headache and cast irritation which resolved within 24 hours.
- Gillick, BT, Zirpel L. Neuroplasticity: An Appreciation From Synapse to System. Archives of Physical Medicine and Rehabilitation. 2012; 93(10): 1846-55. PMID: 22613094
Summary: Discussion of neuroplasticity (the brain's ability to change).
McKnight Land Grant Professor (2017-2019)
New Mexico Brain Injury Conference, Plenary Speaker
American Physical Therapy Association, Eugene Michels New Investigator Award
Representative, Global Professional Education Committee, Int'l Alliance of Academies of Childhood Disability
President Kaler/MnDRIVE Press Conference Speaker to MN Legislature
MN Governor Dayton Pediatric Stroke Awareness Month May 2016 Proclamation Co-Author
Australian Consulate Cerebral Palsy Alliance Award, NYC, NY
NIH Fellowship: Randomized Behavioral Clinical Trials
American Academy of Cerebral Palsy and Developmental Medicine 2015 Plenary Speaker
AAMC Early Career Women Faculty Professional Development Seminar - University of Minnesota Medical School Representative
Developmental Medicine Child Neurology Journal - Editor's Choice Manuscript
American Physical Therapy Association Section on Pediatrics - Best Dissertation Award
Keynote 2013 Graduation Speaker - Doctor of Physical Therapy
Archives of Physical Medicine and Rehabilitation - Top 25 Article Summer 2012
University of Minnesota Clinical and Translational Science Institute - Best Poster Award
Calgary Pediatric Stroke Program provides children with cerebrovascular disease and their families with state-of-the-art diagnosis, treatment, and support while providing the opportunity to participate in leading clinical research initiatives.
Cerebral Palsy Research Registry is a multi-institutional collaborative effort whose primary mission is to improve our understanding of cerebral palsy.
Children's Hemiplegia and Stroke Association exists to help children who have survived an early brain injury that results in hemiplegia or hemiparesis (weakness on one side of the body.
ClinicalTrials.gov is a registry and results database of publicly and privately supported clinical studies of human participants conducted around the world. ClinicalTrials.gov is a service of the U.S. National Institutes of Health.
International Alliance for Pediatric Stroke offers the needed resources, support, inspiration, knowledge and information that will empower you to better understand pediatric stroke.
Research Match is a free and secure registry developed by major academic institutions across the country who want to involve you in helping today's research studies make a real difference for everyone's health in the future.
Novel Neuromodulatory Intervention in the Rehabilitation of Pediatric Hemiparesis
Funding: NIH K01 Career Development Award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development
Timeline: September 2014- June 2019
Project Goals: Evaluate the safety and efficacy of combined tDCS/CIMT in children with hemiparesis; and examine the influence of combined tDCS/CIMT on brain excitability and reorganization
Dr. Gillick's role: Principal Investigator
The Alberta Perinatal Stroke Program: Neuromodulation to Optimize Outcomes
Funding: Canadian Institutes of Health Research
Timeline: July 2015-June 2022
Dr. Gillick's role: Co-investigator
Gillick Lab (map)
426 Church St. SE
Minneapolis, MN 55455-0222
Center for Neurobehavioral Development (map)
717 Delaware Street SE, Ste. 333
Minneapolis, MN 55414
Clinical & Translational Science Institute (map)
Masonic Memorial Building
424 Harvard Street SE
Minneapolis, MN 55455
Center for Magnetic Resonance Research (map)
2021 Sixth Street SE
Minneapolis, MN 55455
320 Children's Rehabilitation Center
426 Church Street SE
Minneapolis, MN 55455
Gillick Pediatric Research Lab
University of Minnesota
420 Delaware Street SE
Minneapolis, MN 55455